How to diagnose and
treat rheumatoid arthritis

How do clinicians diagnose rheumatoid arthritis?

Most people start by noticing a pattern, not a single moment. You might have joints that feel swollen, warm, or tender, morning stiffness that lasts a long time, and symptoms on both sides of the body, like both hands or both feet. Fatigue can be part of it too. These details matter because rheumatoid arthritis is usually an inflammatory condition that affects multiple joints over time.1

At a visit, a clinician will usually focus on:

Your story and daily function

  • Which joints hurt, and whether they look or feel swollen
  • How long morning stiffness lasts
  • What activities are getting harder, like opening jars, typing, walking, or getting dressed1

A physical exam

  • Checking joints for swelling, warmth, tenderness, and range of motion
  • Looking for patterns that fit rheumatoid arthritis, like small joints in the hands, wrists, and feet1

Blood tests, when helpful

  • Tests for antibodies like rheumatoid factor and anti-CCP can support the diagnosis, and can sometimes help estimate the risk of more joint damage over time.5
  • Inflammation markers like C-reactive protein or erythrocyte sedimentation rate can reflect inflammation, but they can be normal even when symptoms are real, especially early on.4 5

Imaging, when needed

  • X-rays of hands and feet may be used to look for joint damage and provide a baseline for the future.4
  • Ultrasound or magnetic resonance imaging may be used in some cases to spot inflammation earlier than X-ray, or to clarify what is happening in a joint.6

If a clinician strongly suspects rheumatoid arthritis, referral to a rheumatologist is often urgent because starting the right treatment early can help prevent permanent joint damage.4

What are the treatment options for rheumatoid arthritis?

Treatment for rheumatoid arthritis is usually step-by-step. The goal is to calm inflammation, protect joints, and help you keep doing the things that matter to you. Most plans combine medication with movement, education, and support for daily life.2 4

  1. Education and activity

Learning what rheumatoid arthritis is, how flares work, and how to pace activities can make symptoms feel more manageable. Self-management strategies are recommended as part of care, alongside medical treatment.4 7

2. Exercise-based rehab

Exercise is generally safe for most people with rheumatoid arthritis, and it can improve strength, fitness, and fatigue when tailored to your symptoms and disease activity.8 9 Programs often include:

  • Aerobic exercise (like walking, cycling, or swimming)
  • Strength training (including hands and upper body)
  • Gentle mobility and flexibility work, especially when stiffness is high8 9

3. Disease-modifying medications

These medications treat the underlying inflammation and help prevent joint damage. Methotrexate is often the first choice, and other options can be added or switched if needed to reach remission or low disease activity.2 4 Options may include:

  • Conventional disease-modifying medications (like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide)2 4
  • Biologic medications (such as tumor necrosis factor inhibitors and other targeted biologics)2 11
  • Targeted synthetic medications (including Janus kinase inhibitors), which can be effective but may not be the right fit for everyone due to safety considerations in higher-risk groups2 11

4. Short-term steroids

Steroids can help calm a flare or bridge the time until long-term medications start working, but guidelines recommend using the lowest effective dose for the shortest time because side effects add up.2 4

5. Anti-inflammatory pain medicines

Non-steroidal anti-inflammatory drugs can reduce pain and swelling, but they do not prevent joint damage, so they are usually add-on symptom relief rather than the core treatment.4

6. Injections

A steroid injection into a specific joint can help when one or two joints are driving most of the pain or swelling, especially during a flare.4

7. Surgery

Surgery is usually considered only when there is severe joint damage, tendon problems, or ongoing pain and disability despite well-optimized medical care.4 1

Recovery timelines vary. Some people improve quickly once inflammation is controlled, while others need several medication adjustments and a longer runway to find steady relief. Treat-to-target monitoring helps keep care moving in the right direction.2 3 4

Sword's approach

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How can I find pain relief for rheumatoid arthritis?

These low-risk strategies can help many people feel more in control day to day, especially alongside medical care:

  • Use pacing, not “push through.” Break bigger tasks into smaller chunks, and alternate heavier and lighter activities to avoid big flare-ups. Self-management approaches like pacing are commonly recommended as part of rheumatoid arthritis care.7
  • Keep joints gently moving when you feel stiff. Short, frequent movement breaks can be easier than a single long workout, especially in the morning. Regular physical activity is recommended, with adjustments for disease activity and your current capacity.8 9
  • Choose joint-friendly movement on tougher days. Walking, cycling, or water-based exercise can reduce stress on painful joints while still supporting fitness.8 9
  • Use supportive tools when needed. Splints, braces, or assistive devices can reduce strain during flares and make tasks like gripping and lifting easier.9
  • Treat flares as a signal to adjust, not a sign of damage from normal movement. Your care team may suggest temporary changes in activity and medication during flares. This is a common part of guideline-based management.2 4

If symptoms persist, suddenly worsen, or you develop a single very hot, swollen joint with fever, contact a clinician urgently since infection needs to be ruled out, especially if you take immune-suppressing medicines.4

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Footnotes

1

World Health Organization. Rheumatoid arthritis. WHO Fact Sheet. 2023. URL: https://www.who.int/news-room/fact-sheets/detail/rheumatoid-arthritis

2

Smolen JS, Landewé RBM, Bergstra SA, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2022. URL: https://ard.bmj.com/content/early/2022/11/10/ard-2022-223356

3

Smolen JS, Breedveld FC, Burmester GR, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75(1):3-15. https://doi.org/10.1136/annrheumdis-2015-207524

4

National Institute for Health and Care Excellence (NICE). Rheumatoid arthritis in adults: management (NG100). 2018; updated 2020. URL: https://www.nice.org.uk/guidance/ng100

5

Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria: an ACR/EULAR collaborative initiative. Ann Rheum Dis. 2010;69(9):1580-1588. https://doi.org/10.1136/ard.2010.138461

6

Colebatch AN, Edwards CJ, Østergaard M, et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis. 2013. https://doi.org/10.1136/annrheumdis-2012-203158

7

Nikiphorou E, Santos EJF, Marques A, et al. 2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis. Ann Rheum Dis. 2021;80(10):1278-1285. https://doi.org/10.1136/annrheumdis-2021-220249

8

Rausch Osthoff A-K, Niedermann K, Braun J, et al. 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis. Ann Rheum Dis. 2018;77(9):1251-1260. https://doi.org/10.1136/annrheumdis-2018-213585

9

England BR, et al. 2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis. Arthritis Care Res. 2022. URL: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.24842

10

Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care Res. 2021;73(7):924-939. https://doi.org/10.1002/acr.24596

11

U.S. Food and Drug Administration. JAK inhibitors: Drug Safety Communication, warnings about increased risk of serious heart-related events, cancer, blood clots, and death. URL: https://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-warnings-about-increased-risk-serious-heart-related-events-cancer-blood-clots-and-death

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